A thorough examination of medical records has revealed that several U.S. military personnel who received a smallpox vaccination suffered from heart inflammation, leading to deaths in some cases, while others experienced persistent inflammation over the years. Autopsies conducted on two young male military members who died unexpectedly showed evidence of myocarditis, or heart inflammation. Additionally, it was found that two other individuals—an 18-year-old male and a 23-year-old female—likely died due to heart inflammation. The study, published in May by PLOS One, was conducted by researchers employed by the Defense Health Agency (DHA), although the lead researcher declined to comment.
The researchers analyzed health records and related documents from cases reported to the Vaccine Adverse Event Reporting System, focusing on members who received the Dryvax or ACAM2000 smallpox vaccine between December 1, 2002, and December 31, 2016. Out of over 5,000 reported adverse events following smallpox vaccination, the researchers identified 352 cases meeting the criteria for myocarditis or pericarditis, including the four deaths. They then reviewed additional records to determine the recovery progress of each affected member.
Among the 306 cases with follow-up data, only 16 individuals recovered within six weeks, while an additional 194 recovered within one year. However, 67 cases took more than a year to recover, and 39 individuals never fully recovered, according to the latest available data. Although the majority of members eventually recovered, the lengthy recovery time, chronic condition in some cases, and deaths raised concerns among experts.
The deaths of the four individuals, although relatively small in number, served as further evidence that vaccine-induced myocarditis can be fatal, even among previously healthy individuals. Autopsies and medical records provided strong evidence linking myocarditis to the two sudden deaths, ruling out other causes. The individuals who died were in good health according to medical records and met military fitness standards, without any conditions affecting their ability to receive the smallpox vaccine.
Heart issues are a recognized side effect of smallpox vaccines, with myocarditis and pericarditis occurring in approximately 1 in 175 first-time recipients of ACAM2000, a vaccine available since 2008. The military in 2018 suspended mandatory administration of anthrax and smallpox vaccines, but some individuals are still receiving them. It is worth noting that COVID-19 vaccines have also been associated with myocarditis, particularly among young males. Long-term data on myocarditis patients vaccinated against COVID-19 indicate that not all individuals recover quickly, with abnormalities observed in follow-up cardiac MRIs and some patients reporting chest pain lasting one year or more after vaccination.
The military researchers in this study suggested that the findings, which include delayed recovery or lack thereof in some individuals, resemble cases of myocarditis/pericarditis following COVID-19 vaccination. However, they noted that long-term outcomes remain to be determined and may involve prolonged stress reactions associated with acute cases of myocarditis/pericarditis in previously healthy individuals who received the vaccine.
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